Insulin-Like Growth Factor I-Induced Degradation of Insulin Receptor Substrate 1 Is Mediated by the 26S Proteasome and Blocked by Phosphatidylinositol 3′-Kinase Inhibition

Insulin receptor substrate 1 (IRS-1) is a critical adapter protein involved in both insulin and insulin-like growth factor (IGF) signaling. Due to the fact that alteration of IRS-1 levels can affect the sensitivity and response to both insulin and IGF-I, we examined the ability of each of these liga...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Lee, Adrian V., Gooch, Jennifer L., Oesterreich, Steffi, Guler, Rebecca L., Yee, Douglas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85315/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10669726/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.5.1489-1496.2000
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