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Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1
Insulin receptor substrate 1 (IRS-1) plays an important role in the insulin signaling cascade. In vitro and in vivo studies from many investigators have suggested that lowering of IRS-1 cellular levels may be a mechanism of disordered insulin action (so-called insulin resistance). We previously repo...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC134643/ https://ncbi.nlm.nih.gov/pubmed/11809794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1016-1026.2002 |
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