Identification of Residues in Yeast Spo11p Critical for Meiotic DNA Double-Strand Break Formation

Saccharomyces cerevisiae Spo11 protein (Spo11p) is thought to generate the DNA double-strand breaks (DSBs) that initiate homologous recombination during meiosis. Spo11p is related to a subunit of archaebacterial topoisomerase VI and appears to cleave DNA through a topoisomerase-like transesterase me...

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Bibliographic Details
Main Authors: Diaz, Robert L., Alcid, Alston D., Berger, James M., Keeney, Scott
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC134631/
https://ncbi.nlm.nih.gov/pubmed/11809802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1106-1115.2002
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