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Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

Based on observations of markers for DNA lesions, such as phosphorylated histone H2AX (γH2AX) and open DNA ends, it has been suggested that post-meiotic DNA double-strand breaks (PM-DSBs) enable chromatin remodeling during animal spermiogenesis. However, the existence of PM-DSBs is unconfirmed, and...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Akematsu, Takahiko, Fukuda, Yasuhiro, Garg, Jyoti, Fillingham, Jeffrey S, Pearlman, Ronald E, Loidl, Josef
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482572/
https://ncbi.nlm.nih.gov/pubmed/28621664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26176
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