Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

Based on observations of markers for DNA lesions, such as phosphorylated histone H2AX (γH2AX) and open DNA ends, it has been suggested that post-meiotic DNA double-strand breaks (PM-DSBs) enable chromatin remodeling during animal spermiogenesis. However, the existence of PM-DSBs is unconfirmed, and...

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Bibliographic Details
Published in:eLife
Main Authors: Akematsu, Takahiko, Fukuda, Yasuhiro, Garg, Jyoti, Fillingham, Jeffrey S, Pearlman, Ronald E, Loidl, Josef
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482572/
https://ncbi.nlm.nih.gov/pubmed/28621664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26176
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