Novel ceftazidime-resistance β-lactamases generated by a codon-based mutagenesis method and selection
Four known and nine new ceftazidime-resistance β-lactamases were generated by a novel, contaminating codon-based mutagenesis approach. In this method, wild-type codons are spiked with a set of mutant codons during oligonucleotide synthesis, generating random combinatorial libraries of primers that c...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134257/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12177312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gnf083 |
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