Cytoplasmic Death Signal Triggered by Src-Mediated Phosphorylation of the Adenovirus E4orf4 Protein

In transformed cells, the adenovirus E4orf4 death factor works in part by inducing a Src-mediated cytoplasmic apoptotic signal leading to caspase-independent membrane blebbing and cell death. Here we show that Src-family kinases modulate E4orf4 phosphorylation on tyrosine residues. Mutation of tyros...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Gingras, Marie-Claude, Champagne, Claudia, Roy, Mélanie, Lavoie, Josée N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134208/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739721/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.1.41-56.2002
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