Cytoplasmic Death Signal Triggered by Src-Mediated Phosphorylation of the Adenovirus E4orf4 Protein

In transformed cells, the adenovirus E4orf4 death factor works in part by inducing a Src-mediated cytoplasmic apoptotic signal leading to caspase-independent membrane blebbing and cell death. Here we show that Src-family kinases modulate E4orf4 phosphorylation on tyrosine residues. Mutation of tyros...

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Bibliografiske detaljer
Main Authors: Gingras, Marie-Claude, Champagne, Claudia, Roy, Mélanie, Lavoie, Josée N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134208/
https://ncbi.nlm.nih.gov/pubmed/11739721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.1.41-56.2002
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