Rapamycin Potentiates Transforming Growth Factor β-Induced Growth Arrest in Nontransformed, Oncogene-Transformed, and Human Cancer Cells

Transforming growth factor β (TGF-β) induces cell cycle arrest of most nontransformed epithelial cell lines. In contrast, many human carcinomas are refractory to the growth-inhibitory effect of TGF-β. TGF-β overexpression inhibits tumorigenesis, and abolition of TGF-β signaling accelerates tumorigen...

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Hlavní autoři: Law, Brian K., Chytil, Anna, Dumont, Nancy, Hamilton, Elizabeth G., Waltner-Law, Mary E., Aakre, Mary E., Covington, Cassondra, Moses, Harold L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC134072/
https://ncbi.nlm.nih.gov/pubmed/12417722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8184-8198.2002
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