Rapamycin Potentiates Transforming Growth Factor β-Induced Growth Arrest in Nontransformed, Oncogene-Transformed, and Human Cancer Cells

Transforming growth factor β (TGF-β) induces cell cycle arrest of most nontransformed epithelial cell lines. In contrast, many human carcinomas are refractory to the growth-inhibitory effect of TGF-β. TGF-β overexpression inhibits tumorigenesis, and abolition of TGF-β signaling accelerates tumorigen...

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Detalhes bibliográficos
Main Authors: Law, Brian K., Chytil, Anna, Dumont, Nancy, Hamilton, Elizabeth G., Waltner-Law, Mary E., Aakre, Mary E., Covington, Cassondra, Moses, Harold L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134072/
https://ncbi.nlm.nih.gov/pubmed/12417722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8184-8198.2002
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