Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

Inhibitors of DNA methyltransferase (Dnmt) and histone deacetylases (HDAC) synergistically activate the methylated metallothionein I gene (MT-I) promoter in mouse lymphosarcoma cells. The cooperative effect of these two classes of inhibitors on MT-I promoter activity was robust following demethylati...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Ghoshal, Kalpana, Datta, Jharna, Majumder, Sarmila, Bai, Shoumei, Dong, Xiaocheng, Parthun, Mark, Jacob, Samson T.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2002
נושאים:
Transcriptional Regulation
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC134057/
https://ncbi.nlm.nih.gov/pubmed/12417732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8302-8319.2002
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים