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Chromium(VI) Down-regulates Heavy Metal-induced Metallothionein Gene Transcription by Modifying Transactivation Potential of the Key Transcription Factor, Metal-responsive Transcription Factor 1

The robust induction of metallothionein-I and II (MT-I and MT-II) genes by several heavy metals such as zinc and cadmium requires the specific transcription factor metal-responsive transcription factor 1 (MTF1). Chromium (VI), a major environmental carcinogen, not only failed to activate these genes...

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Detalhes bibliográficos
Main Authors: Majumder, Sarmila, Ghoshal, Kalpana, Summers, Dennis, Bai, Shoumei, Datta, Jharna, Jacob, Samson T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365495/
https://ncbi.nlm.nih.gov/pubmed/12716893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M302887200
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