Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

Inhibitors of DNA methyltransferase (Dnmt) and histone deacetylases (HDAC) synergistically activate the methylated metallothionein I gene (MT-I) promoter in mouse lymphosarcoma cells. The cooperative effect of these two classes of inhibitors on MT-I promoter activity was robust following demethylati...

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Detalhes bibliográficos
Main Authors: Ghoshal, Kalpana, Datta, Jharna, Majumder, Sarmila, Bai, Shoumei, Dong, Xiaocheng, Parthun, Mark, Jacob, Samson T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134057/
https://ncbi.nlm.nih.gov/pubmed/12417732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8302-8319.2002
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