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RhoGEF Specificity Mutants Implicate RhoA as a Target for Dbs Transforming Activity

Dbs is a Rho-specific guanine nucleotide exchange factor (RhoGEF) that exhibits transforming activity when overexpressed in NIH 3T3 mouse fibroblasts. Like many RhoGEFs, the in vitro catalytic activity of Dbs is not limited to a single substrate. It can catalyze the exchange of GDP for GTP on RhoA a...

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Detalles Bibliográficos
Main Authors: Cheng, Li, Rossman, Kent L., Mahon, Gwendolyn M., Worthylake, David K., Korus, Malgorzata, Sondek, John, Whitehead, Ian P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC134030/
https://ncbi.nlm.nih.gov/pubmed/12215546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.19.6895-6905.2002
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