RhoGEF Specificity Mutants Implicate RhoA as a Target for Dbs Transforming Activity

Dbs is a Rho-specific guanine nucleotide exchange factor (RhoGEF) that exhibits transforming activity when overexpressed in NIH 3T3 mouse fibroblasts. Like many RhoGEFs, the in vitro catalytic activity of Dbs is not limited to a single substrate. It can catalyze the exchange of GDP for GTP on RhoA a...

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Publicado en:	Mol Cell Biol
Autores principales:	Cheng, Li, Rossman, Kent L., Mahon, Gwendolyn M., Worthylake, David K., Korus, Malgorzata, Sondek, John, Whitehead, Ian P.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2002
Materias:	Cell Growth and Development
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134030/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12215546/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.19.6895-6905.2002
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