Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity

DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease III family (nth in Escherichia coli and Nth1 in mammalian organisms) initiate DNA base excision repair of oxidized ring saturated pyrimidine residues. We generated a null mouse (mNth1(−/−)) by gene targeting. After almost...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Ocampo, Maria T. A., Chaung, Wenren, Marenstein, Dina R., Chan, Michael K., Altamirano, Alvin, Basu, Ashis K., Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12167705/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.17.6111-6121.2002
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