Disruption of Mekk2 in Mice Reveals an Unexpected Role for MEKK2 in Modulating T-Cell Receptor Signal Transduction

MEKK2 is a member of the mitogen-activated protein kinase (MAPK) kinase kinase gene family involved in regulating multiple MAPK signaling pathways. To elucidate the in vivo function of MEKK2, we generated mice carrying a targeted mutation in the Mekk2 locus. Mekk2(−/−) mice are viable and fertile. M...

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Bibliographic Details
Main Authors: Guo, Zijian, Clydesdale, Gavin, Cheng, Jinke, Kim, Kihwan, Gan, Lin, McConkey, David J., Ullrich, Stephen E., Zhuang, Yuan, Su, Bing
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133978/
https://ncbi.nlm.nih.gov/pubmed/12138187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.16.5761-5768.2002
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