Interactions between Telomerase and Primase Physically Link the Telomere and Chromosome Replication Machinery

In the ciliate Euplotes crassus, millions of new telomeres are synthesized by telomerase and polymerase α-primase during macronuclear development in mated cells. Concomitant with de novo telomere formation, telomerase assembles into higher-order complexes of 550 kDa, 1,600 kDa, and 5 MDa. We show he...

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Autors principals: Ray, Saugata, Karamysheva, Zemfira, Wang, Libin, Shippen, Dorothy E., Price, Carolyn M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC133977/
https://ncbi.nlm.nih.gov/pubmed/12138196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.16.5859-5868.2002
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