Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA

Telomere dynamics, chromosomal instability, and cellular viability were studied in serial passages of mouse embryonic stem (ES) cells in which the telomerase RNA (mTER) gene was deleted. These cells lack detectable telomerase activity, and their growth rate was reduced after more than 300 divisions...

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Bibliografiske detaljer
Main Authors: Niida, Hiroyuki, Shinkai, Yoichi, Hande, M. Prakash, Matsumoto, Takehisa, Takehara, Shoko, Tachibana, Makoto, Oshimura, Mitsuo, Lansdorp, Peter M., Furuichi, Yasuhiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85781/
https://ncbi.nlm.nih.gov/pubmed/10805753
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