Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA

Telomere dynamics, chromosomal instability, and cellular viability were studied in serial passages of mouse embryonic stem (ES) cells in which the telomerase RNA (mTER) gene was deleted. These cells lack detectable telomerase activity, and their growth rate was reduced after more than 300 divisions...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Niida, Hiroyuki, Shinkai, Yoichi, Hande, M. Prakash, Matsumoto, Takehisa, Takehara, Shoko, Tachibana, Makoto, Oshimura, Mitsuo, Lansdorp, Peter M., Furuichi, Yasuhiro
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2000
Matèries:	DNA Dynamics and Chromosome Structure
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805753/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.11.4115-4127.2000
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