Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA

Telomere dynamics, chromosomal instability, and cellular viability were studied in serial passages of mouse embryonic stem (ES) cells in which the telomerase RNA (mTER) gene was deleted. These cells lack detectable telomerase activity, and their growth rate was reduced after more than 300 divisions...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Niida, Hiroyuki, Shinkai, Yoichi, Hande, M. Prakash, Matsumoto, Takehisa, Takehara, Shoko, Tachibana, Makoto, Oshimura, Mitsuo, Lansdorp, Peter M., Furuichi, Yasuhiro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805753/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.11.4115-4127.2000
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