The Caspase 8 Inhibitor c-FLIP(L) Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes

The caspase 8 inhibitor c-FLIP(L) can act in vitro as a molecular switch between cell death and growth signals transmitted by the death receptor Fas (CD95). To elucidate its function in vivo, transgenic mice were generated that overexpress c-FLIP(L) in the T-cell compartment (c-FLIP(L) Tg mice). As...

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Autors principals: Lens, Susanne M. A., Kataoka, Takao, Fortner, Karen A., Tinel, Antoine, Ferrero, Isabel, MacDonald, Robson H., Hahne, Michel, Beermann, Friedrich, Attinger, Antoine, Orbea, Hans-Acha, Budd, Ralph C., Tschopp, Jürg
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC133948/
https://ncbi.nlm.nih.gov/pubmed/12101236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5419-5433.2002
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