The Caspase 8 Inhibitor c-FLIP(L) Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes

Eitemau Tebyg

• N-Terminal Fragment of c-FLIP(L) Processed by Caspase 8 Specifically Interacts with TRAF2 and Induces Activation of the NF-κB Signaling Pathway
  gan: Kataoka, Takao, et al.
  Cyhoeddwyd: (2004)
• Caspase Activation Is Required for T Cell Proliferation
  gan: Kennedy, Norman J., et al.
  Cyhoeddwyd: (1999)
• NF-κB Signals Induce the Expression of c-FLIP
  gan: Micheau, Olivier, et al.
  Cyhoeddwyd: (2001)
• c-FLIP(S) reduces activation of caspase and NF-κB pathways and decreases T cell survival
  gan: Hinshaw-Makepeace, Jennifer, et al.
  Cyhoeddwyd: (2008)
• Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway
  gan: Tinel, Antoine, et al.
  Cyhoeddwyd: (2007)