Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4 expression results in embryonic lethality (10.5 days postcoitum [dpc]), which was rescued by transferring the Mdm4 mutation into a Trp53-null background. Mutant embryos were...

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Bibliographic Details
Main Authors: Migliorini, Domenico, Denchi, Eros Lazzerini, Danovi, Davide, Jochemsen, Aart, Capillo, Manuela, Gobbi, Alberto, Helin, Kristian, Pelicci, Pier Giuseppe, Marine, Jean-Christophe
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133932/
https://ncbi.nlm.nih.gov/pubmed/12101245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5527-5538.2002
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