Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G(2)/M Phase, and Protection from Apoptosis

Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGFβR, TEL/TRKC(L), and NPM/ALK arise from reciprocal chromosomal translocations and cause acute and chronic leukemias and non-Hodgkin's lymphoma. FTK-transformed cells displayed drug resistance against the cytostatic drugs...

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Detalhes bibliográficos
Main Authors: Slupianek, Artur, Hoser, Grazyna, Majsterek, Ireneusz, Bronisz, Agnieszka, Malecki, Maciej, Blasiak, Janusz, Fishel, Richard, Skorski, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133854/
https://ncbi.nlm.nih.gov/pubmed/12024032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.12.4189-4201.2002
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