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Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

Bim (Bcl-2-interacting mediator of cell death) is a member of the BH3 domain-only subgroup of Bcl-2 family members, for which three splice variants have been described. Bim is expressed in many healthy cell types, where it is maintained in an inactive conformation through binding to the microtubule-...

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Detalhes bibliográficos
Main Authors: Marani, Michela, Tenev, Tencho, Hancock, David, Downward, Julian, Lemoine, Nicholas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133811/
https://ncbi.nlm.nih.gov/pubmed/11997495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.11.3577-3589.2002
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