Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repress apoptosis. A yeast two-hybrid assay accurately reproduced this interaction and defined a selectivity an...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sedlak, T W, Oltvai, Z N, Yang, E, Wang, K, Boise, L H, Thompson, C B, Korsmeyer, S J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41240/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7834
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