Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repress apoptosis. A yeast two-hybrid assay accurately reproduced this interaction and defined a selectivity an...

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Hlavní autoři: Sedlak, T W, Oltvai, Z N, Yang, E, Wang, K, Boise, L H, Thompson, C B, Korsmeyer, S J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC41240/
https://ncbi.nlm.nih.gov/pubmed/7644501
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