Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction

Grb-2-related adaptor protein (Grap) is a Grb2-like SH3-SH2-SH3 adaptor protein with expression restricted to lymphoid tissues. Grap(−/−) lymphocytes isolated from targeted Grap-deficient mice exhibited enhanced proliferation, interleukin-2 production, and c-fos induction in response to mitogenic T-...

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Autori principali: Shen, Randy, Ouyang, Ying-Bin, Qu, Cheng-Kui, Alonso, Andres, Sperzel, Lindsey, Mustelin, Tomas, Kaplan, Mark H., Feng, Gen-Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133801/
https://ncbi.nlm.nih.gov/pubmed/11971956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3230-3236.2002
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