Overcoming Functional Redundancy To Elicit Pachyonychia Congenita-Like Nail Lesions in Transgenic Mice

Mutations affecting the coding sequence of intermediate filament (IF) proteins account for >30 disorders, including numerous skin bullous diseases, myopathies, neuropathies, and even progeria. The manipulation of IF genes in mice has been widely successful for modeling key features of such clinic...

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Detalhes bibliográficos
Main Authors: Wong, Pauline, Domergue, Renee, Coulombe, Pierre A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538767/
https://ncbi.nlm.nih.gov/pubmed/15601842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.197-205.2005
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