Overcoming Functional Redundancy To Elicit Pachyonychia Congenita-Like Nail Lesions in Transgenic Mice

Mutations affecting the coding sequence of intermediate filament (IF) proteins account for >30 disorders, including numerous skin bullous diseases, myopathies, neuropathies, and even progeria. The manipulation of IF genes in mice has been widely successful for modeling key features of such clinic...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Wong, Pauline, Domergue, Renee, Coulombe, Pierre A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC538767/
https://ncbi.nlm.nih.gov/pubmed/15601842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.197-205.2005
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki