Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259

The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped all cAMP-induced phosphorylation sites in Raf-1, showing that serines 43, 259, and 621 are phosphorylat...

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Detalhes bibliográficos
Main Authors: Dhillon, Amardeep S., Pollock, Claire, Steen, Helge, Shaw, Peter E., Mischak, Harald, Kolch, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133783/
https://ncbi.nlm.nih.gov/pubmed/11971957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3237-3246.2002
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