Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259

The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped all cAMP-induced phosphorylation sites in Raf-1, showing that serines 43, 259, and 621 are phosphorylat...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Dhillon, Amardeep S., Pollock, Claire, Steen, Helge, Shaw, Peter E., Mischak, Harald, Kolch, Walter
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11971957/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.10.3237-3246.2002
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