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p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice
The DDB2 gene, which is mutated in xeroderma pigmentosum group E, enhances global genomic repair of cyclobutane pyrimidine dimers and suppresses UV-induced mutagenesis. Because DDB2 transcription increases after DNA damage in a p53-dependent manner, we searched for and found a region in the human DD...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133779/ https://ncbi.nlm.nih.gov/pubmed/11971958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3247-3254.2002 |
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