Central Role for the XRCC1 BRCT I Domain in Mammalian DNA Single-Strand Break Repair

The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1 possesses two BRCA1 carboxyl-terminal (BRCT) protein interaction domains, denoted BRCT I and II. BRCT II is required for SSBR during G(1) but is dispensable for this process d...

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Bibliografiska uppgifter
Huvudupphovsmän: Taylor, Richard M., Thistlethwaite, Angela, Caldecott, Keith W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2002
Ämnen:
DNA Dynamics and Chromosome Structure
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC133733/
https://ncbi.nlm.nih.gov/pubmed/11909950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2556-2563.2002
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