Impaired Cardiac Contractility Response to Hemodynamic Stress in S100A1-Deficient Mice

Ca(2+) signaling plays a central role in cardiac contractility and adaptation to increased hemodynamic demand. We have generated mice with a targeted deletion of the S100A1 gene coding for the major cardiac isoform of the large multigenic S100 family of EF hand Ca(2+)-binding proteins. S100A1(−/−) m...

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Bibliografiske detaljer
Main Authors: Du, Xiao-Jun, Cole, Timothy J., Tenis, Nora, Gao, Xiao-Ming, Köntgen, Frank, Kemp, Bruce E., Heierhorst, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133731/
https://ncbi.nlm.nih.gov/pubmed/11909974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2821-2829.2002
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