Analysis of Sequence Upstream of the Endogenous H19 Gene Reveals Elements Both Essential and Dispensable for Imprinting

Imprinting of the linked and oppositely expressed mouse H19 and Igf2 genes requires a 2-kb differentially methylated domain (DMD) that is located 2 kb upstream of H19. This element is postulated to function as a methylation-sensitive insulator. Here we test whether an additional sequence 5′ of H19 i...

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Détails bibliographiques
Auteurs principaux: Thorvaldsen, Joanne L., Mann, Mellissa R. W., Nwoko, Okechukwu, Duran, Kristen L., Bartolomei, Marisa S.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Transcriptional Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC133727/
https://ncbi.nlm.nih.gov/pubmed/11909940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2450-2462.2002
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