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Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein

A conformational conversion of the normal, protease- sensitive prion protein (PrP-sen or PrP(C)) to a protease-resistant form (PrP-res or PrP(Sc)) is commonly thought to be required in transmissible spongiform encephalopathies (TSEs). Endogenous sulfated glycosaminoglycans are associated with PrP-re...

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Udgivet i:EMBO J
Principais autores: Wong, Cai’ne, Xiong, Liang-Wen, Horiuchi, Motohiro, Raymond, Lynne, Wehrly, Kathy, Chesebro, Bruce, Caughey, Byron
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133469/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157745/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.377
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