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Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein

A conformational conversion of the normal, protease- sensitive prion protein (PrP-sen or PrP(C)) to a protease-resistant form (PrP-res or PrP(Sc)) is commonly thought to be required in transmissible spongiform encephalopathies (TSEs). Endogenous sulfated glycosaminoglycans are associated with PrP-re...

詳細記述

保存先:
書誌詳細
出版年:EMBO J
主要な著者: Wong, Cai’ne, Xiong, Liang-Wen, Horiuchi, Motohiro, Raymond, Lynne, Wehrly, Kathy, Chesebro, Bruce, Caughey, Byron
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133469/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157745/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.377
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