Critical Role of Gap Junction Coupled K(ATP) Channel Activity for Regulated Insulin Secretion

Pancreatic β-cells secrete insulin in response to closure of ATP-sensitive K(+) (K(ATP)) channels, which causes membrane depolarization and a concomitant rise in intracellular Ca(2+) (Ca(i)). In intact islets, β-cells are coupled by gap junctions, which are proposed to synchronize electrical activit...

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Main Authors: Rocheleau, Jonathan V, Remedi, Maria S, Granada, Butch, Head, W. Steven, Koster, Joseph C, Nichols, Colin G, Piston, David W
格式: Artigo
語言:Inglês
出版: Public Library of Science 2006
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1334237/
https://ncbi.nlm.nih.gov/pubmed/16402858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040026
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