Defects in beta cell Ca(2+) signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus

AIMS/HYPOTHESIS: Mutations that render ATP-sensitive potassium (K(ATP)) channels insensitive to ATP inhibition cause neonatal diabetes mellitus. In mice, these mutations cause insulin secretion to be lost initially and, as the disease progresses, beta cell mass and insulin content also disappear. We...

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Autori principali: Benninger, R. K. P., Remedi, M. S., Head, W. S., Ustione, A., Piston, D. W., Nichols, C. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245714/
https://ncbi.nlm.nih.gov/pubmed/21271337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-010-2039-7
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