A Modified Hepatitis B Virus Core Particle Containing Multiple Epitopes of the Plasmodium falciparum Circumsporozoite Protein Provides a Highly Immunogenic Malaria Vaccine in Preclinical Analyses in Rodent and Primate Hosts

Despite extensive public health efforts, there are presently 200 to 400 million malaria infections and 1 to 2 million deaths each year due to the Plasmodium parasite. A prime target for malaria vaccine development is the circumsporozoite (CS) protein, which is expressed on the extracellular sporozoi...

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Autori principali: Birkett, A., Lyons, K., Schmidt, A., Boyd, D., Oliveira, G. A., Siddique, A., Nussenzweig, R., Calvo-Calle, J. M., Nardin, E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Fungal and Parasitic Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC133050/
https://ncbi.nlm.nih.gov/pubmed/12438363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.6860-6870.2002
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