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PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte

Monocyte-to-macrophage differentiation with the cytokine granulocyte–macrophage colony-stimulating factor induces expression of the cyclic nucleotide phosphodiesterase PDE1B2. However, what role PDE1B2 plays in macrophage biology has not been elucidated. We have addressed this question by inhibiting...

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Detalhes bibliográficos
Main Authors: Bender, Andrew T., Beavo, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326187/
https://ncbi.nlm.nih.gov/pubmed/16407168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509972102
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