Perforin-dependent elimination of dendritic cells regulates the expansion of antigen-specific CD8(+) T cells in vivo

The lifespan and survival of dendritic cells (DC) in vivo are potentially critical to the expansion of T cell immune responses. We have previously reported that DC loaded with specific antigen are rapidly eliminated by cytotoxic T lymphocytes (CTL) in vivo, but the site, mechanism, and consequences...

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Bibliographic Details
Main Authors: Yang, Jianping, Huck, Stephanie P., McHugh, Rebecca S., Hermans, Ian F., Ronchese, Franca
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324995/
https://ncbi.nlm.nih.gov/pubmed/16373503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509054103
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