Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

A recurrent somatic activating mutation in the nonreceptor tyrosine kinase JAK2 (JAK2V617F) occurs in the majority of patients with the myeloproliferative disorders polycythemia vera, essential thrombocythemia, myelofibrosis with myeloid metaplasia, and, less commonly, chronic myelomonocytic leukemi...

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Bibliographische Detailangaben
Hauptverfasser: Lu, Xiaohui, Levine, Ross, Tong, Wei, Wernig, Gerlinde, Pikman, Yana, Zarnegar, Sara, Gilliland, D. Gary, Lodish, Harvey
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323216/
https://ncbi.nlm.nih.gov/pubmed/16365288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509714102
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