X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis

The JAK2V617F mutation is present in most patients with polycythemia vera (PV) and in some patients with essential thrombocythemia (ET) and myeloid metaplasia/myelofibrosis (MMM). We sought to investigate the relationship between granulocyte clonality and JAK2V617F allelic ratio. A total of 168 of 1...

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Detalhes bibliográficos
Main Authors: Levine, Ross L., Belisle, Claude, Wadleigh, Martha, Zahrieh, David, Lee, Stephanie, Chagnon, Pierre, Gilliland, D. Gary, Busque, Lambert
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895292/
https://ncbi.nlm.nih.gov/pubmed/16434490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-3900
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