The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

The PIK3CA gene encoding the p110α subunit of Class IA phosphatidylinositol 3-kinases (PI3Ks) is frequently mutated in human tumors. Mutations in the PIK3CB gene encoding p110β, the only other widely expressed Class IA PI3K, have not been reported. We compared the biochemical activity and transformi...

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Hauptverfasser: Zhao, Jean J., Liu, Zhenning, Wang, Li, Shin, Eyoung, Loda, Massimo F., Roberts, Thomas M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317954/
https://ncbi.nlm.nih.gov/pubmed/16339315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508988102
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