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The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal

The negative affective symptoms of opiate withdrawal powerfully motivate drug-seeking behavior and may trigger relapse to heroin abuse. To date, no medications exist that effectively relieve the negative affective symptoms of opiate withdrawal. The corticotropin-releasing factor (CRF) system has bee...

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Detalles Bibliográficos
Main Authors: Contarino, Angelo, Papaleo, Francesco
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317931/
https://ncbi.nlm.nih.gov/pubmed/16339307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506999102
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