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Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A

Clostridium difficile is a major nosocomial pathogen that produces two large protein toxins [toxin A (TcdA) and toxin B (TcdB)] capable of disrupting intestinal epithelial cells. Both belong to the family of large clostridial cytotoxins, which are characterized by the presence of a repetitive C-term...

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Detalhes bibliográficos
Main Authors: Ho, Jason G. S., Greco, Antonio, Rupnik, Maja, Ng, Kenneth K.-S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317924/
https://ncbi.nlm.nih.gov/pubmed/16344467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506391102
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