Structural Basis for Antibody Recognition in the Receptor-binding Domains of Toxins A and B from Clostridium difficile

Clostridium difficile infection is a serious and highly prevalent nosocomial disease in which the two large, Rho-glucosylating toxins TcdA and TcdB are the main virulence factors. We report for the first time crystal structures revealing how neutralizing and non-neutralizing single-domain antibodies...

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Detalhes bibliográficos
Main Authors: Murase, Tomohiko, Eugenio, Luiz, Schorr, Melissa, Hussack, Greg, Tanha, Jamshid, Kitova, Elena N., Klassen, John S., Ng, Kenneth K. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900976/
https://ncbi.nlm.nih.gov/pubmed/24311789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.505917
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