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Alternative Pathways for the Repair of RAG-Induced DNA Breaks
RAG1 and RAG2 cleave DNA to generate blunt signal ends and hairpin coding ends at antigen receptor loci in lymphoid cells. During V(D)J recombination, repair of these RAG-generated double-strand breaks (DSBs) by the nonhomologous end-joining (NHEJ) pathway contributes substantially to the antigen re...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1317616/ https://ncbi.nlm.nih.gov/pubmed/16354685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.131-139.2006 |
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