Exploring the Cellular Activity of Camptothecin-Triple-Helix-Forming Oligonucleotide Conjugates

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by topoisomerase I but exhibit little sequence preference, inducing toxicity and side effects. A convenient strategy to confer s...

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Main Authors: Arimondo, Paola B., Thomas, Craig J., Oussedik, Kahina, Baldeyrou, Brigitte, Mahieu, Christine, Halby, Ludovic, Guianvarc'h, Dominique, Lansiaux, Amélie, Hecht, Sidney M., Bailly, Christian, Giovannangeli, Carine
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317612/
https://ncbi.nlm.nih.gov/pubmed/16354702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.324-333.2006
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